Resolution of racemic mandelic acid

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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26050117, 560 43, C07B 1900

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active

043225489

ABSTRACT:
Process for the optical resolution of racemic mandelic acid which process comprises contacting said racemic mandelic acid with a phenylglycine ester or a phenylglycine ester hydrochloride in a reaction medium, and recovering the D(-)-mandelic acid and L(+)-mandelic acid form; certain D(-) and L(+)-phenylglycine esters and hydrochlorides are provided as novel resolution agents.

REFERENCES:
patent: 2820827 (1958-01-01), Ruschig et al.
patent: 3887606 (1975-06-01), Phillipps et al.
McKenzie, J. Chem. Soc., 75, p. 966, (1899).
Ingersoll et al., J. Amer. Chem Soc., 55, p. 411, (1933).
Roger, J. Chem. Soc., p. 1544, (1935).
Blaschke, Chem. Ber., 107, p. 237, (1974).

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