Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Patent
1996-02-20
1998-12-15
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
435123, C12P 1702, C12P 4100
Patent
active
058495681
ABSTRACT:
A process is disclosed that hydrolyzes, by the action of an epoxide hydrolase of Diplodia gossipina (alternatively named Diplodia gossypina) ATCC 16391 or ATCC 10936, the undesired enantiomer of racemic indene oxide, an epoxide of indan.
REFERENCES:
Boyd, et al., "Structure and Stereochemistry of cis-Dihydro Diol and Phenol Metabolites of Bicyclic Azaarenes . . . ", J. Chem. Soc., Perkin Trans., pp. 1065-1071, 1993.
Chien, et al., "Microbial Transformations of Natural Antitumour Agents.", J. Chem. Soc., Perkin Trans., pp. 1352-1356, 1981.
Pedragosa-Moreau et al., "Microbial Transformations. 28. Enantiocomplementary Epoxide Hydrolyses . . . ", J. Org. Chem., 58, pp. 5533-5536, 1993.
Sutherland, et al., "Enantiomeric Composition of the trans-Dihydrodiols Produced from Phenanthrene by Fungi", Applied & Environ. Microb., vol. 59, No. 7, pp. 2145-2149, Jul. 1993.
Yamada, et al., "Microbial Transformation of (+)-Epoxyaurapten by Pseudomonas aeruginosa", Biosci. Biotech. Biochem., 56 (1), pp. 153-154, 1992.
Holland HL, Biocatalysis 10:65-76 (1994).
Chartrain Michel M.
Rosazza John P. N.
Senanayake Chris H.
Zhang Jinyou
Merck & Co. , Inc.
Saucier Sandra E.
Walton Kenneth R.
Winokur Melvin
LandOfFree
Resolution of racemic indene oxide to yield (1S,2R)-indene oxide does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Resolution of racemic indene oxide to yield (1S,2R)-indene oxide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Resolution of racemic indene oxide to yield (1S,2R)-indene oxide will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1457071