Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Patent
1984-08-17
1987-01-13
Rosen, Sam
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
562401, C07P 4100
Patent
active
046364706
ABSTRACT:
Racemates of optically active amino acid substituted at the carbonyl position wherein the alpha amino acid nitrogen is underivatized and can be resolved using a two phase solvent system. The racemate is dissolved in a substantially water immiscible organic material which is a solvent for said amino acid racemate but not for the corresponding amino acids. The racemate is also dissolved in water (aqueous phase) and is in equilibrium with the racemate in the organic phase. One of the optical isomers of the amino acid racemate in the aqueous phase is enzymatically hydrolyzed to the corresponding amino acid and is recovered. The preferred product is L-phenylalanine.
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Herald William J.
Juettner Paul J.
Rosen Sam
Stauffer Chemical Company
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