Resolution of ibuprofen

Details Resolution of ibuprofen Resolution of ibuprofen

1994-12-22

1997-04-15

Barts, Samuel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562496, C07C 5500

Patent

active

056211406

ABSTRACT:
(S)-ibuprofen may be separated from a mixture of (S)-ibuprofen and (R)-ibuprofen in high yield and enantiomeric purity in a single resolution step using an N-alkyl-D-glucamine as the resolving agent.

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Kaiser, et al., "Isomeric Inversion of Ibuprofen (R)-Enantiomer in Humans", J. Pharm. Sci., 65(2), pp. 269-273 (1976).

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