Resolution of hydroxychroman-2-carboxylic acid esters by enantio

Details Resolution of hydroxychroman-2-carboxylic acid esters by enantio Resolution of hydroxychroman-2-carboxylic acid esters by enantio

1990-10-09

1994-09-20

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514457, 549402, A01N 4316, C07D31104

Patent

active

053489730

ABSTRACT:
Hydroxychroman-2-carboxylic acid esters can be resolved by enantiospecific hydrolysis by the use of liver enzymes, particularly solvent treated (acetone) enzymes. Liver enzymes from calf, cat, dog, eel, goat, lungfish, mouse, rat and seal have been found to be enantiospecific.

REFERENCES:
patent: 4801605 (1989-01-01), Hutchison
N. Cohen et al., "A Novel Total Synthesis of (2 R, 4'R, 8'R-.alpha.-Tocopherol (Vitamin E). Construction of Chiral Chromans from an Optically Active, Nonaromatic Precursor", J.A.C.S. 101:22, 6710 (Oct. 24, 1979).
J. B. Jones, "Enzymes in Organic Synthesis", Tetrahedron 42:13, 3351-3403 (October 1986).
A. Akiyama et al., "Enzymes in Organic Synthesis", Chemtech: 627-634 (October 1988).
C. H. Wong, "Enzymatic Catalysts in Organic Synthesis", Science 244: 1145-1152 (1989).
J. W. Scott et al., "6-Hydroxychroman-2-carboxylic acids: Novel Antioxidants", J. Am. Oil Chem. Soc. 51: 200-203 (1974).

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