Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1988-08-24
1990-05-08
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435280, 435157, 435123, 435132, 435197, 435176, 435177, 435198, 435174, 435180, C12P 1700, C12P 1702, C07P 4100, C12N 920
Patent
active
049238108
ABSTRACT:
A method of resolving glycidyl esters to high enantiomeric excess involves fractionation of hydrolytic enzymes (e.g. lipases) to prepare biocatalysts with high enantioselectivity, and using these catalysts to selectively hydrolyze one enantiomer of the glycidyl esters. Also a method for fractionation includes stirring an aqueous solution of the enzyme with a solid inert adsorbent to provide an adsorbed and non-adsorbed enzyme fraction, where the non-adsorbed fraction displays a higher enantioselectivity than the crude non-fractionated enzyme. Also a composition composed of a glycidyl ester is obtained with an enantiomeric excess of greater than or equal to 97%.
REFERENCES:
patent: 3899395 (1975-08-01), Moskowitz et al.
patent: 3901763 (1975-08-01), Horiuchi et al.
patent: 3905870 (1975-09-01), Kutzbach et al.
patent: 4006059 (1977-02-01), Butler
patent: 4042461 (1977-08-01), Esders et al.
patent: 4045552 (1977-08-01), Kutzbach et al.
patent: 4226938 (1980-10-01), Yoshida et al.
patent: 4421850 (1983-12-01), Daniels et al.
patent: 4472503 (1984-09-01), Matsuo et al.
patent: 4522924 (1985-06-01), Tennent et al.
patent: 4668628 (1987-05-01), Dahod et al.
patent: 4732853 (1988-03-01), Whitesides et al.
Cambou et al., J. Am. Chem. Soc., 106: 2687-2692 (1984).
Lavayre et al., Biotech. Bioeng., 24: 2175-2187 (1982).
Lavayre et al., Biotech. Bioeng., 24: 1007-1013.
Ladner, Wolfgong, E. and Whitesides, George M., "Lipase-Catalyzed Hydrolysis as a Route to Esters of Chiral Epoxy Alcohols"; J.A.C.S., vol. 106, 7250-7251 (1984).
Fox Ellen M.
Walts Alan E.
Genzyme Corporation
Hofer Mark A.
Lilling Herbert J.
McCarter Lowell H.
Zitomer Stephanie W.
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