Resolution of furopyridine enantiomers and synthetic precursors

Details Resolution of furopyridine enantiomers and synthetic precursors Resolution of furopyridine enantiomers and synthetic precursors

1990-05-14

1992-07-14

Elmore, Carolyn

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435118, 435120, 435122, 435156, C12P 702

Patent

active

051302527

ABSTRACT:
A method for resolving racemic mixtures of compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof that includes the steps of reacting the OR.sub.3 group of either compound with an esterifying agent in the case where R.sub.3 is H or a lower alkyl group; sujecting the compound to the action of an esterase capable of preferentially hydrolyzing either the (+) or (-) enantiomeric form of the compound; and separating the unhydrolyzed compound from the hydrolyzed compound.

REFERENCES:
patent: 4916074 (1990-04-01), Yoshida et al.
patent: 4971909 (1990-11-01), Kaneoya et al.
patent: 4985365 (1991-01-01), Mitsuda et al.
patent: 5021345 (1991-06-01), Urban et al.

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