Resolution of d,1-menthol

Details Resolution of d,1-menthol Resolution of d,1-menthol

1982-01-08

1983-11-29

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 3512

Patent

active

044182252

ABSTRACT:
1-Menthol can be readily obtained from racemic menthol by conversion of the latter to the diastereomeric esters of an optically active amino acid and chromatographing the diastereomers. The separation of the diastereomeric esters is relatively insensitive to the support or to the solvent used as eluant, and satisfactory separation occurs under a broad variety of conditions. 1-Menthol can be obtained by base catalyzed hydrolysis of the purified diastereomer with high optical purity.

REFERENCES:
patent: 2760993 (1956-08-01), Chang
patent: 3109018 (1963-10-01), Hanover
patent: 3305591 (1967-02-01), Epstein et al.
patent: 3607651 (1971-09-01), Moroe et al.
patent: 3620918 (1971-11-01), Moroe et al.
patent: 3943181 (1976-03-01), Fleischer et al.
Chem. Eng., May 22, 1978, 62-3.
Harada & Hayakawa Bull., Chem. Soc. Japan, 37, 191, (1964).
Halpern & Westley, Chem. Comm., 421, (1965).
Advances in Chromatography, vol. 16, pp. 177-183, (1978).

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