Resolution of amines

Details Resolution of amines Resolution of amines

1970-04-27

1976-09-14

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260534E, 2605705R, C07C10122

Patent

active

039806987

ABSTRACT:
Optical resolution of a dl-.alpha.-phenyl-.beta.-(lower alkylphenyl)ethylamine is carried out by reacting the dl-amine with L-aspartic acid to form diastereoisomeric salts, subjecting the same to fractional crystallization in a mixture composed of water and a water-miscible organic solvent, and decomposing the separated diastereoisomeric salt with a base individually. The thus obtained optically active .alpha.-phenyl-.beta.-(lower alkylphenyl)ethylamine is used as intermediates for the production of higher fatty acid amides having prominent cholesterol lowering activity.

REFERENCES:
Radke et al., "Journal American Chemical Society", vol. 76, pp. 2801-2803 (1954).

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