Resolution of .alpha.-tertiary carboxylic acid esters using lipa

Details Resolution of .alpha.-tertiary carboxylic acid esters using lipa Resolution of .alpha.-tertiary carboxylic acid esters using lipa

1991-05-08

1993-04-13

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435136, C12P 740

Patent

active

052022609

ABSTRACT:
A method for the resolution of .alpha.-tertiary carboxylic acid esters by partial hydrolysis is disclosed. The partial hydrolysis is carried out by contacting the esters with an aqueous solution in the presence of a lipase derived from Candida lipolytica, and the hydrolysis product is separated from unreacted starting material to obtain the hydrolysis product or the unreacted starting material in enantiomerically enriched form.

REFERENCES:
patent: 3405159 (1968-10-01), Krieger et al.
patent: 3830827 (1974-08-01), Karady et al.
patent: 3895052 (1975-07-01), Karady et al.
patent: 4668628 (1987-04-01), Dahod et al.
Chenault, H. K. et al., J. Am. Chem. Soc. 111:6354-6364 (1989).
Kato Y, Tetrahed. Lett. 28:1303-06 (1987).
Sugai, T. et al, J. Org. Chem. 55:4643-4647 (1990).
Christen, M. et al, J. Chem. Soc. Commun 264-266 (1988).

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