Resolution of .alpha.-pivaloyloxyethyl-(S)-3-(3,4-dihydroxypheny

Details Resolution of .alpha.-pivaloyloxyethyl-(S)-3-(3,4-dihydroxypheny Resolution of .alpha.-pivaloyloxyethyl-(S)-3-(3,4-dihydroxypheny

1981-11-16

1983-09-13

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562401, 562446, C07C10132

Patent

active

044043929

ABSTRACT:
Resolution of the .alpha. and .beta. isomers of .alpha.-pivaloyloxyethyl-(S)-3-(3,6-dihydroxyphenyl)-2-methylalaninate is accomplished by; (a) forming the (+) hydrogen tartrate salt of the mixture; (b) fractionally crystallizing the .beta.-isomer salt; and (c) recovering the .alpha.-isomer from the mother liquor by treatment with first a base and second a mineral acid.

REFERENCES:
patent: 3983138 (1976-09-01), Saari
patent: 3988341 (1976-11-01), Saari et al.
Saari et al., Journal of Medicinal Chemistry 21 746 (1978).

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