Resolution of 3-dimethylamino-2-methylpropiophenone (3-DAMP)

Details Resolution of 3-dimethylamino-2-methylpropiophenone (3-DAMP) Resolution of 3-dimethylamino-2-methylpropiophenone (3-DAMP)

1992-06-16

1993-07-13

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C22100

Patent

active

052275264

ABSTRACT:
In a process for resolving 3-dimethylamino-2-methylpropiophenone (3-DAMP) material, a methanol solution containing a mixture of both 1- and d-enantiomers of 3-DAMP is formed. To this solution, ditoluyl-(L)-tartaric acid or ditoluyl-(D)-tartaric acid is added, so as to precipitate either the 1- or d-enantiomer of 3-DAMP as a salt. The precipitate then is isolated as a salt of a substantially pure enantiomer of 3-DAMP.

REFERENCES:
patent: 2804865 (1957-08-01), L'Italien et al.
patent: 3312733 (1967-04-01), Howe
patent: 4370500 (1983-01-01), Kurose
patent: 4968837 (1990-11-01), Manimaran et al.
Berrang et al, J. Org. Chem., vol. 47, pp. 2643-2647 (1982).

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