Resolution of 3-amino alkylnitriles

Details Resolution of 3-amino alkylnitriles Resolution of 3-amino alkylnitriles

2006-04-11

2006-04-11

Richter, Johann (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S419000, C514S423000, C548S336100, C548S532000, C548S491000, C558S436000, C558S440000

Reexamination Certificate

active

07026345

ABSTRACT:
The present invention relates to chiral N-acetyl-alpha-amino acid salts of optically active β-amino alkylnitriles, and also to a process for preparing optically active β-amino alkylnitriles by resolving racemic β-amino alkylnitriles using chiral N-acetyl-alpha-amino acids as resolving agent.

REFERENCES:
patent: 6610874 (2003-08-01), Allen et al.
patent: 2003/0065207 (2003-04-01), Allen et al.
patent: 2004/0002615 (2004-01-01), Allen et al.
patent: 2004/0087811 (2004-05-01), Dreisbach et al.
patent: 2005/0038281 (2005-02-01), Allen et al.
patent: 2004 238322 (2004-08-01), None
Steer, D. L., et al.,The use of β-amino acids in the design of protease and peptidase inhibitors, Letters In Peptide Science, vol. 8, pp. 241-246, (2002).
Steer, D. L., et al.,β-amino Acids: Versatile Peptidomimetics, Current Medicinal Chemistry, vol. 9, pp. 811-822, (2002).
Marshall, R. et al.,Cobalt Ion Activation of Renal Acylase I, J. J. Am. Chem. Soc., vol 78, pp. 4636-4642, (1956).
English translation of JP 2004-238322.

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