Resolution of 2-(6-methoxy-2-napthyl)propionic acid

Details Resolution of 2-(6-methoxy-2-napthyl)propionic acid Resolution of 2-(6-methoxy-2-napthyl)propionic acid

1975-01-13

1976-10-26

Morgenstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260DIG8, 260284, C07B 2100, C07B 1900, C07C 5142

Patent

active

039883655

ABSTRACT:
Resolution of mixtures of d and 1,2-(6-methoxy-2-napthyl)propionic acid with cinchonidine to yield the d-isomer is conducted by using, in combination with the cinchonidine, an inorganic base having a basicity, pKa, greater than 8 and forming a salt of 2-(6-methoxy-2-napthyl)propionic acid more soluble than the solubility of the corresponding cinchonidine salts. After the cinchonidine salt product is cleaved by treatment with a strong base at about room temperature in methanol, the methanolic solution is mixed with sufficient water to precipitate the cinchonidine in a form which is easy to filter. After removal of the precipitated cinchonidine, acidification yields a product enriched in d 2-(6-methoxy-2-napthyl)propionic acid.

REFERENCES:
patent: 3683015 (1972-08-01), Dyson
patent: 3904683 (1975-09-01), Day et al.
Gilman, "Org. Chem.," Wiley & Sons, Inc., N.Y. (1958) pp. 256-258.

Affiliated with

Also associated with

Rating

Resolution of 2-(6-methoxy-2-napthyl)propionic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Resolution of 2-(6-methoxy-2-napthyl)propionic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Resolution of 2-(6-methoxy-2-napthyl)propionic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-184704