Resiniferatoxin and analogues thereof to cause sensory afferent

Details Resiniferatoxin and analogues thereof to cause sensory afferent Resiniferatoxin and analogues thereof to cause sensory afferent

1988-10-24

1990-07-03

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

A61K 3112

Patent

active

049391496

ABSTRACT:
The present invention relates to a method for desensitizing a subject animal, which comprises administering to the subject animal a therapeutically effective desensitizing amount of resiniferatoxin for desensitizing the subject animal to neurogenic inflammation, to chemically and thermally induced pain and to responses involving sensory afferent pathways sensitive to capsaicin and to responses involving the hypothalamic temperature control region, and a pharmaceutically acceptable carrier therefor.

REFERENCES:
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Schmidt, R. et al., Carcinogenesis, 1983; 4(1): 77-81.
Adolf, W. et al., J. Nat. Prod., May-Jun. 1982; 45(3): 347-54.
Driedger, P. E. et al., Cancer Res., May 1980; 40(5): 1400-4.
Hartley, J. A. et al., Cancer Res., Oct. 1985; 45(10): 4864-70.
Yamasaki, H. et al., Carcinogenesis, 1982; 3(8): 905-10.
Edwards, M. C. et al., Mol. Pharmacol., May 1983; 23(3): 703-8.
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