Resin support for solid phase peptide synthesis

Details Resin support for solid phase peptide synthesis Resin support for solid phase peptide synthesis

1987-03-30

1988-08-16

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

525 5411, 526286, 5263471, A61K 3702, C08K28300

Patent

active

047645946

ABSTRACT:
A resin and method for preparing the resin for solid phase peptide synthesis. The resin has a sulfoxide linkage, which is stable to strong acid conditions. The sulfoxide linkage can be reduced to a sulfide linkage, which allows cleavage of the peptide from the resin under mild acid conditions.

REFERENCES:
patent: 3995094 (1976-11-01), Crosby et al.
patent: 4507230 (1985-03-01), Tam et al.
patent: 4623484 (1986-11-01), Carpino et al.
patent: 4680339 (1987-07-01), Fong
Samanen et al, "The p-methylsulfinylbenzyl Group, A Selectively Cleavable Carboxyl Protecting Group", 9th American Peptide Symposium in Toronto, pp. 225-228, 23-28 Jun. 1985.

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