Research apparatus

Details Research apparatus Research apparatus

1984-07-23

1986-10-07

Tudor, Harold J.

Surgery

Truss

Pad

12820423, 128720, 128725, A61B 508

Patent

active

H00001457

ABSTRACT:
A 75-liter plexiglass chamber has been constructed to simultaneously expose 0 rats to a test vapor. Each rat is confined in a small plexiglass plethysmographic box attached to the large chamber. During exposure, the respiration rate, tidal volume, body temperature, pH, and blood gases are measured. A sample of the blood may be used to measure the amount of a volatile test chemical reaching the blood or to measure blood pCO.sub.2 pO.sub.2, and pH. This apparatus optimizes animal usage by permitting many sequential measurements on a minimum number of test animals. Since the animals are exposed simultaneously, the interanimal variations in exposure are minimized.

REFERENCES:
patent: 3976053 (1976-08-01), Reininghaus
patent: 4221211 (1980-09-01), Brasch
patent: 4402315 (1983-09-01), Tsuda et al.

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