Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2011-03-22
2011-03-22
Qian, Celine X (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C435S325000, C435S070100, C536S024100
Reexamination Certificate
active
07910362
ABSTRACT:
A reporter vector which can evaluate the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 and a method for evaluation of the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 by using the reporter vector. A reporter system which can evaluate the ability of a drug capable of inducing CYP1A2 or both of CYP1A1 and CYP1A2 is completed by constructing a reporter vector having a reporter gene linked to the 3′ end of a region between CYP1A1 and CYP1A2 or a reporter vector having different reporter genes linked to the both ends of the region, respectively, so as to sandwich the region, and a reporter vector having a deletion mutation in the region, and confirming that the expression of a reporter molecule is increased by the drug capable of inducing CYP1A2 or both of CYP1A1 and CYP1A2 in the reporter system using the reporter vector.
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Kusano Kazutomi
Nagata Kiyoshi
Ueda Rika
Yamazoe Yasushi
EISAI R&D Management Co., Ltd.
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
Qian Celine X
Tohoku University
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