Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2008-09-02
2008-09-02
Campell, Bruce (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C424S185100, C424S186100, C424S206100
Reexamination Certificate
active
09984057
ABSTRACT:
The present invention provides methods for identifying a class of peptides referred to as replikins and methods of using replikins to stimulate the immune system of a subject. The method of identifying replikin peptides is based on identifying amino acid sequences comprising 7 to about 50 amino acids that contain (1) at least one lysine residue located six to ten residues from a second lysine residue; (2) at least one histidine residue; and (3) at least 6% lysine residues.
REFERENCES:
patent: 5104854 (1992-04-01), Schlesinger et al.
patent: 5231167 (1993-07-01), Zanetti et al.
patent: 5280113 (1994-01-01), Rademacher
patent: 5679352 (1997-10-01), Chong
patent: 5866690 (1999-02-01), Bogoch
patent: 6023659 (2000-02-01), Seilhamer
patent: 6070126 (2000-05-01), Kokolus
patent: 6242578 (2001-06-01), Bogoch
patent: 6256647 (2001-07-01), Toh
patent: 6638505 (2003-10-01), Bogoch
patent: 2005/0271676 (2005-12-01), Sette et al.
patent: 0108564 (1984-05-01), None
patent: 98MI0874 (1999-10-01), None
patent: 96/32106 (1996-10-01), None
patent: WO 00/18351 (2000-04-01), None
patent: 0104135 (2001-01-01), None
Brumeanu et al., Journal of Virology 1997 vol. 71, No. 7, pp. 5473-5480.
NCBI accession# NP—740460, residues 201-210.
Shi et al., Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccin 1999 PNAS vol. 96, No. 4, pp. 1615-1620.
Gao et al., Identification and characterization of T helper epitopes in the nucleoprotein of influenza A virus. J Immunol 1989 Vo 143, pp. 3007-3014.
Rodman, et al., Human immunodeficiency virus (HIV) Tat-reactive antibodies present in normal HIV-negative sera and depleted in HIV-positive sera. Identification of the epitope. J. Exp. Med. 175: 1247-1253.
Weber et al. Virology 1988 vol. 164, pp. 30-38).
Database Medline on STN, National Library of Medicine, (Bethesda, MD, USA), No. 89028479, Bogoch et al.: In vitroproduction of the general transformation antibody related to survival in human cancer patients: antimalignin antibody; Abstract, Cancer Detection and Prevention, 1988, vol. 12, Nos. 1-6, pp. 313-320.
Pannifer, et al. “Crystal structure of the anthrax lethal factor,”Nature, vol. 414, pp. 229-233, (Nov. 2001).
Zhao, et al. “Neutralizing monoclonal antibody against Anthrax lethal factor inhibits intoxication in a mouse model,”Human Antibodies, vol. 12, pp. 129-135, (2003).
Brown, L. R. et al., “Recognition of the influenza hemagglutinin by Class II MHC-restricted T lymphocytes and antibodies,”Journal of Immunology, Oct. 15, 1991, pp. 2677-2684, vol. 147, No. 8, American Association of Immunologists, USA, XP002371257, ISSN: 0022-1767.
Atassi, M. Z. et al., “A novel approach for localization of the continuous protein antigenic sites by comprehensive synthetic surface scanning: Antibody and T cell activity to several influenza hemagglutinin synthetic sites,”Immunological Communications, 1984, pp. 539-551, vol. 13, No. 6, Marcel Dekker, Inc., XP009062995, ISSN: 0090-0877.
Carr, C. M. et al., “A spring-loaded mechanism for the conformational change of influenza hemagglutinin,”Cell, May 21, 1993, pp. 823-832, vol. 73, Cell Press, XP002059698, ISSN: 0092-8674.
Ben-Yedidia, T. et al., “Intranasal administration of peptide vaccine protects human/mouse radiation chimera from influenza infection,”International Immunology, 1999, pp. 1043-1051, XP000914818, ISSN: 0953-8178.
Schenk, S. et al., “Four recombinant isoforms of aCor a1, the major allergen of hazel pollen, show different reactivities with allergen-specific T-lymphocyte clones,”European Journal of Biochemistry, 1994, pp. 717-722, vol. 224, XP002371408, ISSN: 0014-2956.
Orlando, C. et al., “A monoclonal antibody directed against the catalytic site ofBacillus anthracisadenylyl cyclase identifies a novel mammalian brain catalytic subunit,”Biochemistry, 1992, pp. 3215-3222, vol. 31, American Chemical Society, XP002371438, ISSN: 0006-2960.
Supplementary Partial European Search Report 03721445.9, Dec. 12, 2006, EPO, International Searching Authority, Munich, DE.
PCT International Search Report, PCT/US2002/09240, Jan. 14, 2004, USPTO, International Searching Authority, Washington, DC.
PCT International Preliminary Examination Report, PCT/US2002/09240, Feb. 5, 2004, USPTO, International Preliminary Examination Authority, Alexandria, VA, USA.
PCT International Search Report, PCT/US2002/21494 , May 30, 2003, USPTO, International Searching Authority, Washington DC.
PCT International Preliminary Examination Report, PCT/US2002/21494 , Nov. 26, 2004, USPTO, International Searching Authority, Alexandria, VA, USA.
PCT International Search Report, PCT/US2003/08990, Dec. 7. 2005 , International Searching Authority, USPTO, Alexandria, VA, USA.
PCT International Search Report, PCT/US2004/017936, Apr. 28, 2005, EPO, International Searching Authority, Rijswijk, NL.
PCT Written Opinion of the International Searching Authority, PCT/US2004/017936, Apr. 7, 2005, EPO, International Searching Authority, Munich, DE.
PCT International Preliminary Report on Patentability, PCT/US2004/017936, Apr. 13, 2007, USPTO, International Preliminary Examining Authority, Alexandria, VA, USA.
PCT International Preliminary Report on Patentability, PCT/US2005/014443, Nov. 1, 2006, WIPO, International Bureau of WIPO, Geneva, Switzerland.
PCT Written Opinion of the International Searching Authority, PCT/US2005/014443, Apr. 12, 2006, EPO, International Searching Authority, Munich, DE.
Bogoch, S. et al., “A Checklist for Suitability of Biomarkers as Surrogate Endpoints in Chemoprevention of Breast Cancer,” Journal of Cellular Biochemistry, Supplement, Boston, US, vol. 19, pp. 173-185, XP009046492, ISSN: 0733-1959, 1994.
Bucher, D. et al., “M protein (M1) of influenza virus antigenic analysis and intracellular localization with monoclonal antibodies”, J Virol. Sep. 1989; 63(9): pp. 3622-3633.
Chambers, T.M. et al., “Antigenic and molecular characterization of subtype H13 hemagglutinin of influenza virus,” Database NCBI on STN, Accession No. HMIVT2, Virology, pp. 180-188, abstract, 1989, 172(1).
Gelder, C.M. et al., “Human CD4+ T-cell repertoire of response to influnza A virus hemagglutinin after recent natural infection,” Journal of Virology, Dec. 1995, vol. 69, No. 12, pp. 7497-7506A.
Tanaka, T. et al., “Efficient Generation of Antibodies to Oncoproteins by using Synthetic Peptide Antigens.” Proceedings of the National Academy of Sciences of USA, National Academy of Science, Washington, D.C., US, v. 82, No. 10, p. 3400-3404, tables 1, Peptide 21, XP000113798, ISSN: 0027-8424, May 1, 1985.
3MOTIF—Search Instructions, 3motif in three Dimensions, article titles “Submitting a protein sequence”: http://brutlag.stanford.edu/3motif/search—instr.html).
NCBI accession # gi 75059 Jul. 16, 1999.
NCBI Listing JQ0032, residues 74-82, May 11, 2000.
NCBI Query Tutorial “Introduction” (http://www.ncbi.nim.nih.gov/Education/BLASTinfo/query—tutorial.html).
NCBI Query Tutorial “Introduction to a Blast Query” (http://www.ncbi.nim.nih.gov/Education/BLASTinfo/tut1.html).
NCBI Query Tutorial “Setting up a Blast Search” (http://www.ncbi.nim.nih.gov/Education/BLASTinfo/Blast—setup.html).
NCBI Blast Searching, Gene Gateway—Exploring Genes and Genetic Disorders, “Sequence similarity searching using NCBI Blast” (http:www.ORNL.gov/sci/techresources/Himan—Genome/chromosome/blast.shtml).
Abrams M. B. et al., “Early Detection and Monitoring of cancer with the Anti-Malignin Antibody Test,” Cancer detection and Prevention, XX, XX, vol. 18, No. 1, 1994, pp. 65-78, XP000673180, ISSN:0361-090X.
Bogoch et al., “Aglyco Pathology of Viral Receptors in Dementias,” Annals of the New York Academy of Sciences, New York Academy of Sciences, New York, NY, US, vol. 757, 1995, pp. 413-417, XP008003395, ISSN:0077-8923.
Keppeler
Bogoch Elenore S.
Bogoch Samuel
Campell Bruce
Hill Myron G.
Kenyon & Kenyon LLP
LandOfFree
Replikins and methods of identifying replikin-containing... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Replikins and methods of identifying replikin-containing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Replikins and methods of identifying replikin-containing... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3940198