Replicons of pestviruses that do not express C and or E1...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S093200, C424S093600, C424S204100, C424S218100, C435S235100, C435S236000, C435S325000, C435S456000, C536S023720

Reexamination Certificate

active

10524210

ABSTRACT:
The present invention provides new Pestiviral RNA genomes (replicons) that are able to replicate, and can be packaged into infectious viral particles in cells that complement the missing protein(s), but do not produce infectious progeny virus. Such replicons can be useful for vaccine purposes.

REFERENCES:
patent: 6180109 (2001-01-01), Moormann et al.
patent: 2004/0052818 (2004-03-01), Heinz et al.
patent: 1 035 205 (2000-09-01), None
patent: 1 149 901 (2001-10-01), None
patent: WO 01 39801 (2001-06-01), None
patent: WO 2002 066621 (2002-08-01), None
Widjojoatmodjo M.N. et al.: “Classical swine fever virus Erns deletion mutants: Trans-complementation . . . ” J. of Virology (Apr. 2000) V74, N7, p. 2973-2980, XP002227585.
Rumenapf, T. et al.: “Processing of the Envelope Glycoproteins of Pestiviruses” Journal of Virology, Jun. 1993, 67:6, 3288-3294.

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