Replication protein a binding transcriptional factor (RBT1)...

Details Replication protein a binding transcriptional factor (RBT1)... Replication protein a binding transcriptional factor (RBT1)...

2006-08-22

2006-08-22

Whiteman, Brian (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S455000, C530S350000

Reexamination Certificate

active

07094891

ABSTRACT:
The present invention relates to replication protein A (RPA) transcriptional factors. There is provided a nucleotide sequence encoding a replication protein A transcriptional activator 1 (RTB1) and a protein encoded by such a nucleotide sequence. RBT1 has a high activity and is highly transactivated in cancer cells. The sequence may be used to treat neoplastic disorders and in gene therapy.

REFERENCES:
patent: WO98/00013 (1998-01-01), None
patent: WO98/37901 (1998-09-01), None
Gerhold et al. BioEssays, 18:973-981, 1996.
Attwood, Science 290:471-473, 2000.
Singh et al. (1995), “,”92 Proceedings of the National Academy of Science USA11:4907-4911.
Hillier et al. (1997), “zt34d02.rl Soares Ovary Tumor NbHOT Homo sapiens cDNA Clone IMAGE : 724227 5′, mRNA Sequence,” Database EM—EST 'Online! EMBL; ID HS1272698, AC AA482412 98.5% nt seq idenity with SEQ ID No.: 1 in 495 nt overlap (14-506 : 60-554).
Marra et al. (1997), “vt32d01.rl Barstead Mouse Proximal Colon MPLRB6 Mus Musculus cDNA Clone IMAGE: 1164769 5′, mRNA Sequence” Database EM—EST 'Online! EMBL; ID AA690874 81.3% nt seq identity with SEQ ID No.: 1 in 402 nt overlap (9-410 : 190-591).
Nagelhus et al. (1997), “A Sequence in the N-Terminal Region of Human Uracil-DNA Glycosylase with Homology to XPA Interacts with the C-Terminal Part of the 34-kDa Subunit of Replication Protein A,” 272Journal of Biological Chemistry, 10:6561-6566.
Wold (1997), “Replication Protein A: A Heterotrimeric, Single-Stranded DNA-binding Protein Required for Eukaryotic DNA Metabolism,”66 Annual Review of Biochemistry61-92 XP001002023 cited in the applicaton abstract p. 74, line 17 -p. 76, line 27.
Hays et al. (1998), “,”18 Molecular and Cellular Biology7:4400-4406.
Iftode et al. (1999), “Replication Protein A (RPA): the Eukaryotic SSB,”34 Critical Reviews in Biochemistry and Molecular Biology3:141-180, XP001002021 abstract figure 1 p. 159, left-hand col., line 34 -p. 166, left-hand col., line 29; table 2.
Database EM—HUM 'Online! EMBL ID AC010271 (1999) “Homo sapiens Chromosome 19 CTC-492K19, Complete Sequence,” Doe Joint Genome Institute Stanford Human Genome Center XP002167207 99.8% nt seq identity with SEQ ID No.: 1 in 591 nt overlap (23191-23781:1-591) p. 6-7.
Cho et al. (2000), “RBT1, a Novel Transcriptional Co-activator, Binds the Second Subunit of Replication Protein A,”28 Nucleic Acids Research18:3478-3485 XP002167204 the whole document.

Affiliated with

Also associated with

Rating

Replication protein a binding transcriptional factor (RBT1)... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Replication protein a binding transcriptional factor (RBT1)..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Replication protein a binding transcriptional factor (RBT1)... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3618473