Replication protein

Details Replication protein Replication protein

2003-12-05

2010-11-16

Ketter, James S (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S024310

Reexamination Certificate

active

07833702

ABSTRACT:
This invention relates to a screening method for the identification of agents which modulate the activity of a DNA replication protein as a target for intervention in cancer therapy and includes agents which modulate said activity. The invention also relates to the use of the DNA replication protein, and its RNA transcripts in the prognosis and diagnosis of proliferative disease e.g., cancer.

REFERENCES:
patent: WO 00/58473 (2000-10-01), None
patent: WO 01/53312 (2001-07-01), None
patent: WO 01/70979 (2001-09-01), None
patent: WO 01/72777 (2001-10-01), None
Database EMBL EBI, Strausberg R.L. et al; “Mus musculus CDKN1A interacting zinc finger protein 1, mRNA (cDNA clone MGC: 27988 Image: 3597692), complete cds”, Dec. 10, 2001, XP 002285021, Database accession No. BC018483, abstract, Hinxton, Cambridgeshire, UK.
Database GENESEQ EBI, Hillman, JL et al; Human transcription factor TRFX-47, Feb. 5, 2002, XP002285018, Database accession No. ABB50196, abstract, Hinxton, Cambridgeshire, UK.
Database GENESEQ EBI, Shimkets RA; Leach M: “Human ORFX ORF3109 polynucleotide sequence SEQ ID No. 6217” Feb. 8, 2001, XP002285019, Database accession No. AAC77554, abstract, Hinxton, Cambridgeshire, UK.
Database GENESEQ EBI, Tang YT. et al, “Human polypeptide SEQ ID No. 2772”, Oct. 22, 2001, XP 002285017, Database accession No. AAM39627 abstract, Hinxton, Cambridgeshire, UK.
Database UNIPROT EBI, Mitsui K et al, Cipl-interacting zinc finger protein (Nuclear protein NP94) Oct. 16, 2001, XP002285016, Database accession No. Q9ULV3 abstract, Hinxton, Cambridgeshire, UK.
Database UNIPROT EBI, Strausberg R: “Hypothetical protein (CIZI)” Mar. 1, 2002, XP002285020, Database accession No. Q8VEH2, abstract, Hinxton, Cambridgeshire, UK.
Database UNIPROT EBI, The Fantom Consortium & The Riken Genome Exploration Research Group Phase I & II Team: “LSFR1 protein homolog”, Mar. 1, 2003, XP-002285015, Database accession No. Q8BIT2 abstract, Hinxton, Cambridgeshire, UK &.
Mitsui Kaoru et al: “Cloning and characterization of a novel p21 Cipl/Wafl-interacting zinc finger protein, Cizl” Biochemiical and Biophysical Research Communications, vol. 264, No. 2, Oct. 22, 1999, pp. 457-464, XP002285057, ISSN: 006-291X.
The Fantom Consortium & The Riken Genome Exploration Research Group Phase I & II Team, “Analysis of the Mouse Transcriptome Based on a Functional Annotation of 60, 770 Full-Length CDNAS” Nature, MacMillan Journals Ltd, London, UK, vol. 420, No. 6915, Dec. 5, 2002, pp. 563-573, XP001165660, ISSN: 0028-0836.

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