Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-05-16
2000-10-24
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Vector, per se
424 931, 424 932, C12N 1586, A01N 6300
Patent
active
061365947
ABSTRACT:
The present invention relates to a replication deficient recombinant adenovirus vector in the genome of which is inserted an expression cassette comprising the DNA fragment coding for the human CFTR protein, said DNA fragment being placed under the control of the elements for the expression thereof.
The present invention also concerns a vector according to claim 1 wherein in the expression cassette the human CFTR gene is under the control of the endogenous human CFTR promoter.
REFERENCES:
patent: 4920209 (1990-04-01), Davis et al.
patent: 5240846 (1993-08-01), Collins et al.
Boucher, 1996, "Current Status of CF Gene Therapy", TIG 12:81-84.
Brody et al., 1994, "Acute Responses of Non-Human Primates to Airway Delivery of an Adenovirus Vector Containing the Human Cystic Fibrosis Transmembrane Conductance Regulator cDNA", Hum. Gene Ther. 5:821-836.
Collins, 1992, "Cystic Fibrosis: Molecular Biology and Therapeutic Implications", Science 256:774-779.
Rosenfeld et al., 1992, "In Vivo Transfer of the Human Cystic Fibrosis Transmembrane Conductance Regulator Gene to the Airway Epithelium", Cell 68:143-155.
Chengalvalva et al., 1991, "Adenovirus Vectors for Gene Expression", Curr. Biol. 2:718-722.
Levrero et al., 1991, "Defective and Nondefective Adenovirus for Expressing Foreign Genes In Vitro and In Vivo", Gene 101:195-202.
Rosenfeld, 1991, "Adenovirus-Mediated Transfer of a Recombinant .alpha..sub.1 -Antitrypsin Gene to the Lung Epithelium in Vivo", Science 252:431-433.
Crystal et al., 1990, New Viral Transfer Systems, Abstract Presented at the North American Cystic Fibrosis Conference, Arlington, Virginia, Oct. 3-6.
Drumm et al., 1990, "Correction of the Cystic Fibrosis Defect In Vitro by Retrovirus by Retrovirus-Mediated Gene Transfer", Cell 62:1227-1233.
Gilardi et al., 1990, "Expression of Human .alpha..sub.1 -Antitrypsin Using a Recombinant Adenovirus Vector", FEBS 267:60-62.
Stratford-Petricaudet et al., 1990, "Evaluation of the Transfer and Expression in Mice of an Enzyme-Encoding Gene Using a Human Adenovirus Vector", Hum. Gene Ther. 1:241-256.
Chasse et al., 1989, "L'Adenovirus: Vecteur de Therapie Genique?", Medecine/Sciences 5:331-337.
Chasse et al., 1989, "Human Recombinant Adenovirus Used to Correct a Mouse Enzyme Deficiency", Abstract Presented at the Meeting on Regulation of Gene Expression, Cold Spring Harbor, May 3-7.
Chasse et al., 1989, "Somatic Gene Therapy of a Mouse Enzyme Deficiency Using a Recombinant Adenovirus", J. Cell. Biochem. S13B:174 (Abstract F120).
Ginsberg et al., 1989, "Role of Early Region 3 (E3) in Pathogenesis of Adenovirus Disease", Proc. Natl. Acad. Sci. USA 86:3823-3827.
Hubbard et al., 1989, "Fate of Aerosolized Recombinant DNA-Produced .alpha..sub.1 -Antitrypsin: Use of the Epithelial Surface of the Lower Respiratory Tract to administer Proteins of Therapeutic Importance", Proc. Natl. Acad. USA 86:680-684.
Riordan et al., 1989 "Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA", Science 245:1066-1072.
Ballay et al., 1987, "Hepatitis B Adenovirus Recombinants as a Potential Live Vaccine", Hepadna Viruses (Alan R. Liss, Inc.) pp. 481-493.
Ballay et al., 1985, "In Vitro and In Vivo Synthesis of the Hepatitis B Virus Surface Antigen and of the Receptor for Polarized Human and Serum Albumin from Recombinant Human Adenoviruses", EMBO J. 4:3861-3865.
Long et al., 1984, "Complete Sequence of the cDNA for Human .alpha..sub.1 Antitrypsin and the Gene for the S Variant", Biochem. 23:4828-4837.
Shenk and Williams, 1984, "Genetic Analysis of Adenoviruses", Current Topics in Microbiology and Immunology 111:1-39.
Hanahan, 1983, "Studies and Transformation of Escherichia coli with Plasmids", J. Mol. Biol. 166:557-580.
Thimmappaya et al., 1982, "Adenovirus VAI RNA Is Required for Efficient Translation of Viral mRNAs at Late Times after Infection", Cell 31:543-551.
Kapoor and Chinnadurai, 1981, "Method for Introducing Site-Specific Mutations into Adenovirus 2 Genome: Construction of a Small Deletion Mutant in VA-RNA.sub.1 Gene", Proc. Natl. Acad. Sci. USA 78:2184-2188.
Graham et al., 1977, "Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5", J. Virol. 36:59-72.
Dalemans Wilfried
Pavirani Andrea
Perricaudet Michel
Stratford-Perricaudet Leslie
Chambers Jasemine C.
Clark Deborah J. R.
Transgene S.A.
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