Replication deficient adenovirus vectors and methods of...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Reexamination Certificate

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C435S455000, C435S456000, C435S325000, C435S457000, C435S471000, C435S475000, C435S369000, C435S320100, C424S093200

Reexamination Certificate

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06867022

ABSTRACT:
The invention provides novel replication deficient adenovirus vectors and methods for making and using these viruses. The invention also provides vector systems and kits using a serotype specific strategy for making adenoviral vector preparations substantially free of replication competent “helper” virus. The helper virus-free preparations provide novel pharmaceutical compositions substantially free of helper virus for use in gene transfer and gene therapy.

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