Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-01-31
1999-10-12
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
435 691, 435 693, 4353201, 435325, 4241991, 4242011, 4242171, 4242161, 514 44, 536 231, A01N 6300
Patent
active
059651245
ABSTRACT:
Replication-competent recombinant viruses, particularly replication-competent recombinant polioviruses, which include (1) exogenous nucleic acid sequences which encode an exogenous polypeptide and (2) a nucleic acid sequence which encodes an artificial proteolytic cleavage site for a viral or cellular protease which proteolytically processes (cleaves) the precursor protein produced by the parent virus and uses therefor. The recombinant precursor is cleaved into the usual array of constituent proteins, freeing the exogenous polypeptide. Replication-competent recombinant viruses are useful as vaccines against bacterial, viral, fungal and yeast infections, parasitic diseases, cancer and allergies.
REFERENCES:
patent: 5162601 (1992-11-01), Slightom
Fields et al, Virology Third Edition, Lippincott-Raven Press, Chapter 21, Picornaviridae: The viruses and Their Replication, 1996.
Whalen (Emerging Infectious Disease, vol. 2, No. 3:168-175, 1996).
Etlinger, Immunology Today, 13, 2, 52-55, 1992.
Lerner, R.A. et al. (1983) in: The Biology of Immunologic Disease, F.J. Dixon & D.W. Fisher, eds., HP Publishing Co, Inc., New York, NY., pp. 331-338.
Rose, C.S. et al. (1991) Trends in Biotechnol. 9:415-421.
Carrington, J.C. et al. (1988) Proc. Natl. Acad. Sci USA 85:3391-3395.
Blair, W.S. et al. (1990) J. Virol. 64: 1784-1793.
Nicklin, M.J. et al. (1988) J. Virol. 62:4586-4593.
Evans, D.J. et al. (1989) Nature 339: 385-388.
Burke, K. et al. (1989) J. Gen. Virol. 70:2475-2479.
Whelan, S.P.J. and Almond, J.W., Abstract from Europic '91, the Seventh Meeting of the European Study Group on the Molecular Biology of Picornaviruses, The University of Kent at Canterbury, U.K. Aug. 24th-30th, 1991.
Hagino-Yamagishi, K. and Nomoto, A., Abstract from Europic '91, the Seventh Meeting of the European Study Group on the Molecular Biology of Picornaviruses, The University of Kent at Canterbury, U.K. Aug. 24th-30th, 1991.
Almond, J.W. et al., Abstract F6 in Abstracts from Europic '91, the Seventh Meeting of the European Study Group on the Molecular Biology of Picornaviruses, The University of Kent at Canterbury, U.K. Aug. 24th-30th, 1991.
Konig, Herbert, et al., "Purification and Partial Characterization of Poliovirus Protease 2A by Means of a Functional Assay," J. of Virology, pp. 1243-1250 (1988).
Pallai, Peter V., et al., "Cleavage of Synthetic Peptides by purified Polioviruses 3C Proteinase," J. Biol Chemistry 264:9738-9741 (1989).
Ansardi, David C., et al., "Coinfection with Recombinant Vaccinia Viruses Expressing Poliovirus P1 and P3 Proteins Results in Polyprotein Processing and Formation of Empty Capsid Structures," J. of Virology 65:2088-2092 (1991).
Deideu, J.F. et al., Abstract D30 in abstracts from Europic '91, the Seventh Meeting of the European Study Group on the Molecular Biology of Picornaviruses, The University of Kent at Canterbury, U.K. 24th-30th 1991.
Murdin, A.D. et al., Abstract from Europic '91, the Seventh Meeting of the European Study Group on the Molecular Biology of Picornaviruses, The University of Kent at Canterbury, U.K. 24th-30th 1991.
Evans, D.J. et al., Abstract D12 from Europic '91, the Seventh Meeting of the European Study Group on the Molecular Biology of Picornaviruses, The University of Kent at Canterbury, U.K. 24th-30th 1991.
Burke, K.L. et al., "Antigen Chimaeras of Poliovirus as Potential New Vaccines," Nature 332:81-82 (1988).
Iizuka, N. et al., "Construction of Less Neurovirulent Polioviruses by Introducing Deletions into the 5' Noncoding Sequence of the Genome," Journal of Virology 63(12):5354-5363 (1989).
Kuge, S. and Nomoto, A., "Construction of Viable Deletion and Insertion Mutants of the Sabin Strain of Type 1 Poliovirus: Function of the 5' Noncoding Sequence in Viral Replication," Journal of Virology 61(5):1478-1487 (1987).
Kohara, M. et al., "A Recombinant Virus between the Sabin 1 and Sabin 3 Vaccine Strains of Poliovirus as a Possible Candidate for a New Type 3 Poliovirus Live Vaccine Strain," Journal of Virology 62(8):2828-2835 (1988).
Feinberg, M. et al., "Novel Recombinant Poliovirus Vectors" Abst., The Rockefeller Univ., NY, NY 10021, USA. The Gladstone Institute of Virology & Immunology. University of California, San Francisco, CA 94110, for the Third International Symposium on Positive Strand RNA Viruses in Clearwater, FL, Sep. 19-24, 1992.
Andino Raul
Feinberg Mark
Reilly Patricia Anne
Weeks-Levy Carolyn Louise
American Cynamid Company
Campell Bruce R.
Nguyen Dave Trong
Whitehead Institute for Biomedical Research
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