Replication-competent Herpes simplex virus mediates destruction

Details Replication-competent Herpes simplex virus mediates destruction Replication-competent Herpes simplex virus mediates destruction

1998-01-08

2000-10-31

Campbell, Bruce R.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

A01N 6300, A61K 4800

Patent

active

061398349

ABSTRACT:
A method for killing malignant brain tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with defective expression of the .gamma.34.5 gene and the ribonucleotide reductase gene, specifically destroys tumor cells, is hypersensitive to anti-viral agents, and yet is not neurovirulent.

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Chahlavi, et al. "Replication-Competent Herpes simplexVirus Vector G207 and Cisplatin Combination Theapy for Head and Neck Squamous Cell Carcinoma", Neoplasia 1(2):162-169 (Jun. 2, 1999).
Toda, et al. "Herpes simplexVirus as an in Situ Cancer Vaccine for the Induction of Spectrum Anti-Tumor Immunity", Human Gene Therapy 10:385-393 (Feb. 10, 1999).
Nilaver, et al. "Delivery of herpesvirus and adenovirus to nude rat intracerebral tumors after osmotic blood-brain barrier disruption", Proc. Natl. Acad. Sci. USA 92:9829-9833 (Oct. 1995).
Neuwelt et al. "Delivery of ultraviolet-inactivated .sup.35 S-herpesvirus across an osmotically modified blood-brain barrier", J. Neurosurg 74:475-479 (Mar. 1991).
Walker, et al. "Local and systemic therapy of human prostate adenocarcinoma with the conditionally replicating Herpes simplexvirus vector G207", Human Gene Therapy, pp. 1-28 (In Press Sep. 1999).

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