Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1994-06-23
1996-12-17
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
4242051, 4242291, 4351723, 4352351, 435236, 4353201, 935 32, A01N 6300, A61K 4800, A61K 3912, A61K 39245
Patent
active
055850960
ABSTRACT:
A method for killing malignant brain tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with defective expression of the .sub..gamma. 34.5 gene and the ribonucleotide reductase gene, specifically destroys tumor cells, is hypersensitive to anti-viral agents, and yet is not neurovirulent.
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Martuza Robert L.
Mineta Toshihiro
Rabkin Samuel D.
Campell Bruce R.
Georgetown University
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