Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1990-09-28
1992-12-01
Yarbrough, Amelia Burgess
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 91, 436811, 935 78, C12Q 168, C12P 1934
Patent
active
051680394
ABSTRACT:
A novel composition and/or methods for the diagnosis of tuberculosis wherein the composition comprises a repetitive DNA segment that is specific for members of the Mycobacterium tuberculosis complex. The DNA segment repeats in the chromosome of Mycobacterium tuberculosis complex, and is conserved in all copies of the chromosomes. A method comprises using an entire repetitive DNA sequence, or any part thereof, as a hybridization probe for the direct detection of Mycobacterium tuberculosis complex in clinical material. In another method, a smaller portion of an entire repetitive DNA sequence is amplified using polymerase chain reaction, yielding a 123 base-pair product.
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Eisenach et al., Polymerase Chain Reaction Amplification of a Repetitive DNA Sequence Specific for Mycobacterium tuberculosis, Journal of Infectious Diseases, vol. 161, 1990, pp. 977-981.
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Bates Joseph H.
Cave M. Donald
Crawford Jack T.
Eisenach Kathleen D.
Burgess Yarbrough Amelia
Ivester Hermann
The Board of Trustees of the University of Arkansas
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