Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1991-10-01
1993-02-02
Yarbrough, Amelia Burgess
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 91, 4351723, 436501, 935 78, C12G 168
Patent
active
051837374
ABSTRACT:
A novel composition and/or methods for the diagnosis of tuberculosis wherein the composition comprises a repetitive DNA segment that is specific for members of the Mycobacterium tuberculosis complex. The DNA segment repeats in the chromosome of Mycobacterium tuberculosis complex, and is conserved in all copies of the chromosomes. A method comprises using an entire repetitive DNA sequence, or any part thereof, as a hybridization probe for the direct detection of Mycobacterium tuberculosis complex in clinical material. In another method, a smaller portion of an entire repetitive DNA sequence is amplified using polymerase chain reaction, yielding a 123 base-pair product.
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Eisenach et al., Polymerase Chain Reaction Amplification of a Repetitive DNA Sequence Specific for Mycobacterium Tuberculosi Journal of Infectious Diseases, vol. 161, 1990, pp. 977-981.
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Thierry et al., IS6110, an IS-like Element of Mycobacterium Tuberculosis Complex, Nucleic Acids Research vol. 18, No. 1 1990, p. 188.
Bates Joseph H.
Cave M. Donald
Crawford Jack T.
Eisenach Kathleen D.
Burgess Yarbrough Amelia
Ivester Hermann
The Board of Trustees of the University of Arkansas
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