Repair of ruptured membrane by injection of naturally...

Surgery – Instruments – Sutureless closure

Reexamination Certificate

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C424S581000

Reexamination Certificate

active

07744625

ABSTRACT:
The present invention provides compositions and methods for use in treatment of premature rupture of membrane. The compositions of the invention include a therapeutic amount of an avian thick egg white composition. Preferably, the compositions include the purified thick egg white protein, ovomucin. The methods of the invention involve injecting an effective amount of the compositions into the prematurely ruptured amniotic sac of a patient in order to seal the rupture.

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patent: 6541447 (2003-04-01), Dawson
patent: 7175647 (2007-02-01), Berry
patent: 2007/0160679 (2007-07-01), Berry
Awade et al., “Two-step chromatographic procedure for the purification of hen egg white ovomucin, lysozyme, ovotransferrin and ovalbumin and characterization of purified proteins,”J. Chromat. A, 677:279-288, 1994.
Awade and Efstathiou, “Comparison of three liquid chromatographic methods for egg-white protein analysis,”J. Chromat. B, 723:69-74, 1999.
Bejar et al., “Premature labor. II. Bacterial sources of phospholipase,”Obstet. Gynecol. 57:479-482, 1981.
Galask et al., “Bacterial attachment to the chorioamniotic membranes,”Am. J. Obstet. Gynecol. 148: 915-928, 1984.
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Luks et al., “Gelatin sponge plug to seal fetoscopy port sites: technique in ovine and primate models”;Am J. Obstet Gynecol, 181:995-996, 1999.
MacDonnell et al., “The functional properties of the egg-white proteins,”Food Technol. 9:49-53, 1955.
Miller et al., “Bacterial colonization of amniotic fluid from intact fetal membranes,”Am. J. Obstet. Gynecol. 136:796-804, 1980.
Rabouille et al., “Interactions involved in ovomucin gel-forming properties: a rheological-biochemical approach,”Archives of Biochem.&Biophys., 270: 495-503, 1989.
Rabouille et al., “The Supramolecular Organization of Ovomucin. Biophysical and Morphological Studies,”Biochemical Journal, 266:697-706, 1990.
Saade et al., “Amniotic septostomy for the treatment of twin oligohydramnios-polyhydramnios sequence,”Fetal Diagn Ther, 13:86-93, 1998.
Strecker et al., “1H and13C-NMR assignments for sialylated oigosaccharide-alditols related to mucins. Study of thirteen components from hen ovomucin and swallow nest mucin,”Biochimie74:39-52, 1992.

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