Repair of cartilage and bones

Details Repair of cartilage and bones Repair of cartilage and bones

1984-03-21

1987-02-10

Apley, Richard J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

Bone

623 11, 623 66, 623 15, 128 92R, 128 92W, 128156, 128 92YG, 128 92YR, 128 92YQ, 424 95, 435244, 435245, A61F 228, A61F 202

Patent

active

046421203

ABSTRACT:
There are provided compositions for repairing defects of cartilage and bones. These are provided in gel form either as such, or embedded in natural or artificial bones. The gel comprises certain types of cells. These may be committed embryonal chondocytes or any kind of mesenchyme originated cells which potentially can be converted to cartilage cells, generally by the influence of chondrogenic inducing factors, in combination with fibrinogen, antiprotease and thrombin. The cells ought to be of the species to which the composition is transplanted. It is advantageous to incorporate in the gel extracellular matrix (ECM) of chondrocytes or other hormones and/or growth factors such as SM (Somatomedin=IGF-I), FGF (fibroblast growth factor), CGF (cartilage growth factor), BDGF (bone derived growth factor) or a combination of any of these.

REFERENCES:
"Bone Cell Differentiation and Growth Factors"; Urist et al., Science (Washington, DC), 1983, 220 (4598), 680-6.

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