Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2004-09-24
2008-09-16
Smith, Carolyn (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C703S002000, C435S325000, C435S385000, C436S063000
Reexamination Certificate
active
07426440
ABSTRACT:
A method of scoring the biological activity of bioactive agents like colostrum comprising conducting separate bioassays for cell restitution and cell proliferation on the bioactive agent, a comparative growth factor stimulating agent, and (preferably) a negative baseline control sample containing the cells and growth medium alone. These values are then plugged into the equations provided in this application to calculate a Restitution Score (“RS”), Proliferation Score (“PS”), and a composite repair and protection factor score (“RPF”). In this manner, the bioactivity of compositions that enhance the repair and/or proliferation of mammalian cells, or act as additives to growth media used to maintain and grow laboratory cell cultures can be quickly and reproducibly obtained. This invention may be applied to a wide variety of bioactive agents used to treat a large assortment of functional cells in organ tissues.
REFERENCES:
patent: 3706769 (1972-12-01), Rosen et al.
patent: 3708577 (1973-01-01), Berger
patent: 3790669 (1974-02-01), Gale
patent: 3839587 (1974-10-01), Hoffmann et al.
patent: 3956521 (1976-05-01), Pisecky et al.
patent: 4141970 (1979-02-01), Chidlow et al.
patent: 4281024 (1981-07-01), Hauberg et al.
patent: 4342747 (1982-08-01), Liotet et al.
patent: 4440860 (1984-04-01), Klagsbrun
patent: 4977137 (1990-12-01), Nichols et al.
patent: 5130305 (1992-07-01), Palepu et al.
patent: 5143727 (1992-09-01), Ebina
patent: 5143848 (1992-09-01), Scholten et al.
patent: 5258178 (1993-11-01), Cordle et al.
patent: 5500229 (1996-03-01), Aalto et al.
patent: 5534493 (1996-07-01), Gluckman et al.
patent: 5681586 (1997-10-01), Gordon
patent: 5710127 (1998-01-01), Gluckman et al.
patent: 6258383 (2001-07-01), Gohlke et al.
patent: 6277813 (2001-08-01), Kelly
patent: 6379676 (2002-04-01), Richardson
patent: 6475511 (2002-11-01), Gohlke et al.
patent: 6521591 (2003-02-01), Smeets et al.
patent: 6645472 (2003-11-01), Anderson
patent: 6645510 (2003-11-01), Coury et al.
patent: 2001/0009681 (2001-07-01), Gohlke et al.
patent: 2001/0048948 (2001-12-01), Crum et al.
patent: 2002/0012722 (2002-01-01), Prosise et al.
patent: 2002/0187200 (2002-12-01), Gohlke et al.
patent: 2003/0003059 (2003-01-01), Dana
patent: 2003/0008016 (2003-01-01), Crum et al.
patent: 2003/0068391 (2003-04-01), Harris et al.
patent: 2003/0198688 (2003-10-01), Cockrum
patent: 0 295 009 (1988-12-01), None
patent: 0 331 755 (1989-09-01), None
patent: 0 338 229 (1989-10-01), None
patent: 0 936 917 (2003-11-01), None
patent: 0 927 042 (2004-02-01), None
patent: 2 811 204 (2002-01-01), None
patent: WO 98/11904 (1998-03-01), None
patent: WO 2004/041004 (2004-05-01), None
patent: WO 2006/019960 (2006-02-01), None
McKaig et al., “Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-beta3”, 1999, American Journal of Physiology Gastrointestine Liver Physiology, vol. 276, pp. 1087-1093.
Kelly, G., “Bovine colostrums: A review of clinical uses,”Alternative Medicine Review, vol. 8, No. 4, pp. 378-394 (2003).
The terms “Extract”, “Bioactive”, and “derivative”Merriam-Webster Online Dictionary, http//www.m-w.com, 3 pages (Date Printed Nov. 4, 2005).
FitzGerald, A. et al., “Synergistic effects of systemic trefoil factor family I (TFF1) peptide and epidermal growth factor in a rat model of colitis,”Peptides, vol. 25, pp. 793-801 (2004).
Marchbank, T. et al., “Dimerization of human pS2 (TFF1) plays a key role in its protective/healing effects,”Journal of Pathology, vol. 185, pp. 153-158 (1998).
White, S. et al., “Role of Very Late Adhesion Integrins in Mediating Repair of Human Airway Epithelial Cell Monolayers after Mechanical Injury,”American Journal of Respiratory Cell and Molecular Biology, vol. 20, pp. 787-796 (1999).
Playford, R. et al., “Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders,”Am. J. Clin. Nutr., vol. 72, pp. 5-14 (2000).
Talley, N., “Pharmacologic Therapy for the Irritable Bowel Syndrome,”Am. J. Gastroenterol, vol. 98, No. 4, pp. 750-758 (Apr. 2003).
Abe, M., et al., “Glycyrrhizin Enhances Interleukin-10 Production by Liver Dendritic Cells in Mice With Hepatitis,”Journal of Gastroenterology38(10): 962-67 (2003).
Armanini, D., et al., “Effect of Licorice on the Reduction of Body Fat Mass in Healthy Subjects,”Journal of Endocrinol. Invest. 26: 646-50 (Jul. 2003).
Bardhan, K.D., et al., “Clinical Trial of Deglycyrrhizinized Liquorice in Gastric Ulcer,”Gut19: 779-82 (Sep. 1978).
Borrelli, F. and Izzo, A.A., “The Plant Kingdom As a Source of Anti-Ulcer Remedies,”Phytotherapy Research14: 581-91 (2000).
Chadwick, B., et al., “Hexetidine Mouthrinse in the Management of Minor Apthous Ulceration, and as an Adjunct to Oral Hygiene,”British Dent. J., 171: 83-7 (1991).
Chen, A.C. and Donovan, S.M., “Genistein at a Concentration Present in Soy Infant Formula Inhibits Caco-2BBe Cell Proliferation By Causing G2/M Cell Arrest,” American Society for Nutritional Sciences Manuscript No. 0022-3166/04 (2004).
“Colostrum and IBS”Gut Reaction, The Journal of the IBS Network, Issue 50, Jul. 2003 http://www.colostrum-uk.com
ews/article.asp?articleid=94.
“Colostrum” http://www.crohns.net/Miva/education/colostrum.shtml (Jul. 1, 2004).
U.S. Appl. No. 10/892,939, “Colostrum-Based Treatment for Irritable Bowel Syndrome,” filed Jul. 16, 2004.
U.S. Appl. No. 10/953,244, “Improved Bioactive Agent Compositions For Repair of Cell Injuries,” filed Sep. 29, 2004.
Daniel et al. “Effect of Casein and Beta-Casomorphins on Gastrointestinal Motility in Rats,”J Nutr. 120(3): 252-57 (1990).
Dignass, A., Devaney, K.L., Kindon, H. et al., “Trefoil Peptides Promote Epithelial Migration Through a Transforming Growth Factor Beta Independent Pathway,”J. Clin. Invest. 376-83 (1994).
Dunlop, et al. “Randomized, Double Blind, Placebo-Controlled Trial of Prednisolone in Post-Infectious Irritable Bowel Syndrome,”Aliment Pharmacol Ther18: 77-84 (2003).
“Feedback on Neovite and Digestive Health,” http://www.colostrum-uk.com
ews/article.asp?articleid=82 (Jul. 1, 2004).
Franco, L., et al., “Anti-Ulcer Activity of Carbenoxolone and ISF 3401 on PGE2 Release in Rat Gastric Mucosa,”Pharmacological Research27(2): 141-50 (Feb.-Mar. 1993.
Fung, W.P., “Effect of Soya Bean Milk on the Healing of Gastric Ulcers—A Controlled Endoscopic Study,”Med. J. Aust. 1(23): 717-18 (1975).
Funk. M.A. and Baker, D.H., “Effect of Soy Products on Methotrexate Toxcity in Rats,”Journal of Nutrition121(10): 1684-92 (Oct. 1991).
Ghosh, S. and Playford, R.J., “Bioactive Natural Compounds for the Treatment of Gastrointestinal Disorders”,Clinical Science104, 547-56 (2003).
Gordon, S.R. and Wood, M., “Soybean (Glycine Max) Agglutinin Binds to Corneal Endothelial Cells During Wound Repair and Alters Their Microfilament Pattern,”Cell Molecular Biology43(3): 329-36 (May 1997).
“Irritable Bowel and IBD,” http://www.evenbetternow.com/irritable-bowel-syndrome.html (Jul. 1, 2004).
Jones, et al. “British Society of Gastroenterology Guidelines for the Management of the Irritable Bowel Syndrome,”Gut(Suppl II) 47: ii1-ii19 (2000).
Khan, Z., et al., “Use of the Nutriceutical, Bovine Colostrum, for the Treatment of Distal Colitis: Results from an Initial Study,”Ailment Pharmacological Therapy16: 1917-22 (2002).
Li, Z; et al., “Effects of Soybean Agglutinin on Nitrogen Metabolism and on Characteristics of Intestinal Tissues and Pancreas in Rats,”Arch. Tierernahr. 57(5): 369-80 (Oct. 2003).
Madisch, A., et al., “A Plant Extract and Its Modified Preparation in Functional Dyspepsia,”Z. Gastroenterology39: 511-17 (Jul.
Nutritional Bioscience Ltd.
Smith Carolyn
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