Rep-max protein having anti-oncogenic activity and uses thereof

Details Rep-max protein having anti-oncogenic activity and uses thereof Rep-max protein having anti-oncogenic activity and uses thereof

1998-09-22

2000-10-31

LeGuyaden, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

C07K 500

Patent

active

061404764

ABSTRACT:
The present invention provides a rep-max fusion gene which encodes a Rep-max protein capable of suppressing the oncogenic activity of a Myc family oncoprotein. The present invention further provides a vector containing nucleic acid encoding a Rep-max protein, a vector capable of expressing Rep-max protein and a recombinant viral vector capable of introducing nucleic acid encoding Rep-max protein into a target cell. Finally, the present invention provides a method for suppressing the oncogenic activity of the Myc family oncoproteins in a tumor cell and for inhibiting the growth of a tumor in a subject.

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