Chemistry: molecular biology and microbiology – Vector – per se
Patent
1996-02-29
1998-09-22
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Vector, per se
435 6, 4351723, 435 691, 935 57, 935 32, 935 34, C12N 1563, C12N 1579, C12N 1509
Patent
active
058112987
ABSTRACT:
The present invention provides a rep-max fusion gene which encodes a Rep-max protein capable of suppressing the oncogenic activity of a Myc family oncoprotein. The present invention further provides a vector containing nucleic acid encoding a Rep-max protein, a vector capable of expressing Rep-max protein and a recombinant viral vector capable of introducing nucleic acid encoding Rep-max protein into a target cell. Finally, the present invention provides a method for suppressing the oncogenic activity of Myc family oncoproteins in a tumor cell and for inhibiting the growth of a tumor in a subject.
REFERENCES:
Miller et al. (1995) FASEB J. 9:190-199.
Marshall, E (1995) Science 269:1050-1055.
Crystal R-G (1995) Science 270:404-410.
DePinho Ronald
Schreiber-Agus Nicole
Albert Einstein College of Medicine of Yeshiva University (a Div
Chambers Jasemine C.
Hauda Karen M.
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