Rep-max protein having anti-oncogenic activity and uses thereof

Chemistry: molecular biology and microbiology – Vector – per se

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435 6, 4351723, 435 691, 935 57, 935 32, 935 34, C12N 1563, C12N 1579, C12N 1509

Patent

active

058112987

ABSTRACT:
The present invention provides a rep-max fusion gene which encodes a Rep-max protein capable of suppressing the oncogenic activity of a Myc family oncoprotein. The present invention further provides a vector containing nucleic acid encoding a Rep-max protein, a vector capable of expressing Rep-max protein and a recombinant viral vector capable of introducing nucleic acid encoding Rep-max protein into a target cell. Finally, the present invention provides a method for suppressing the oncogenic activity of Myc family oncoproteins in a tumor cell and for inhibiting the growth of a tumor in a subject.

REFERENCES:
Miller et al. (1995) FASEB J. 9:190-199.
Marshall, E (1995) Science 269:1050-1055.
Crystal R-G (1995) Science 270:404-410.

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