Renoprotective treatments employing vasodilator compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514248, 514259, 514400, 514401, 514646, 514929, A61K 3154, A61K 31135, A61K 31415, A61K 31445, A61K 31475, A61K 31495, A61K 31505

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045321353

ABSTRACT:
A treatment method and substances have been found to reduce the risk of incurring renal damage or failure. Vasodilators useful for the treatment of hypertension have been found to lower cholesterol levels and prevent renal failure or damage. These substances are administered alone or in combination with other substances useful in the treatment of hyperlipidemia such as phenoxyacetic acid derivatives. Suitable vasodilators include: hydralazine hydrochloride and functionally similar agents such as endralazine, trimazosin, minoxidil, and diazoxide; prazosin hydrochloride and functionally similar agents such as doxazosin, triodazosin, phentolamine hydrochloride, phenoxybenzamine hydrochloride, benextramine, indoramine, and yohimbine; clonidine HCl and functionally similar agents such as guanabenz, guanfacine, lofexidine, and UK No. 14,304; labetalol and other combined alpha and beta blocking agents such as prizidolol and peroxidil.

REFERENCES:
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patent: 4255432 (1981-03-01), Kluge et al.
patent: 4377581 (1983-03-01), Hess et al.
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Kirkendull et al., JAMA, vol. 240, No. 23, pp. 2553-2556, 12/1/78.
Griffiths et al., USAN and the USP Dictionary of Drug Names, (1980), pp. 121, 145, 245, 292, 293, 388, 389.
The Merck Index, 9th Ed., (1976), p. 9764.

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