Renin-inhibitory pepstatin phenyl derivatives

Details Renin-inhibitory pepstatin phenyl derivatives Renin-inhibitory pepstatin phenyl derivatives

1987-10-01

1989-10-17

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, 530332, H61K 3743, C07K 510

Patent

active

048747459

ABSTRACT:
A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and congestive heart failure.

REFERENCES:
patent: 4746648 (1988-05-01), Wagnon et al.
The Journal of Antibiotics, 1975, pp. 1016-1017, vol. 28, No. 12.

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