Renin-inhibitory pepstatin phenyl derivatives

Details Renin-inhibitory pepstatin phenyl derivatives Renin-inhibitory pepstatin phenyl derivatives

1989-06-02

1990-12-25

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 713, 4352535, 435898, 514 18, 530330, 530332, C12P 2104, C12R 155

Patent

active

049802836

ABSTRACT:
A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and congestive heart failure.

REFERENCES:
patent: 4415152 (1979-04-01), Celmer et al.
patent: 4415669 (1983-11-01), Hernandez
patent: 4465771 (1984-08-01), Nogami et al.
patent: 4504580 (1985-03-01), Hanada et al.
patent: 4575489 (1986-03-01), Higashide et al.
patent: 4746648 (1988-05-01), Wagnon et al.
patent: 4874745 (1989-10-01), Huang et al.

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