Renin inhibitors, treatments and dipeptide synthesis

Details Renin inhibitors, treatments and dipeptide synthesis Renin inhibitors, treatments and dipeptide synthesis

1984-11-13

1986-09-02

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514 18, 530387, 530328, 530329, A61K 3764, C07K 502, C07K 702

Patent

active

046096434

ABSTRACT:
Preparation of renin inhibitors based on the structure of natural renin substrate at residues 6 to 13 from the amino terminal thereof, the inhibitors being polypeptide analogues having in particular an isosteric non-peptide link corresponding to the 10, 11 peptide link of the substrate, and preparation of dipeptide analogues.

REFERENCES:
patent: 4424207 (1984-01-01), Szelke et al.
Chemical Abstracts, 97, 624(1982), Abst. No. 39405p.
Chemical Abstracts, 98, 726(1983), Abst. No. 54442n.
Chemical Abstracts, 89, 122(1978), Abst. No. 100494v.

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