Renin inhibitors, processes for preparing them, methods for usin

Details Renin inhibitors, processes for preparing them, methods for usin Renin inhibitors, processes for preparing them, methods for usin

1992-08-04

1994-02-22

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530333, 530335, A61K 3702, C07K 500

Patent

active

052888517

ABSTRACT:
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, novel intermediates useful in the preparation thereof, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

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