Renin inhibitors, method for using them, and compositions contai

Details Renin inhibitors, method for using them, and compositions contai Renin inhibitors, method for using them, and compositions contai

1989-07-24

1991-11-05

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, 530331, A61K 3702, C07K 508, C07K 510

Patent

active

050632078

ABSTRACT:
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, novel intermediates useful in the preparation thereof, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

REFERENCES:
patent: 4812555 (1989-03-01), Raddatz et al.
patent: 4857650 (1989-08-01), Iizuka et al.
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601.
Denkewalter et al., Progress in Drug Research, 1966, vol. 10, pp. 510-512.
Plattner et al., J. Med. Chem., 1988, 31(12), 2277-2288.

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