Renin inhibitors containing the 2-[[(2R,3S)-3-amino-4-cyclohexyl

Details Renin inhibitors containing the 2-[[(2R,3S)-3-amino-4-cyclohexyl Renin inhibitors containing the 2-[[(2R,3S)-3-amino-4-cyclohexyl

1991-09-09

1992-05-19

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, A61K 3700

Patent

active

051149257

ABSTRACT:
Compounds of the formula: ##STR1## which are potent inhibitors of human renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory compounds, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these conditions which employ these novel compounds.

REFERENCES:
patent: 4609641 (1986-09-01), Evans et al.
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4711958 (1987-12-01), Iizuka et al.
patent: 4940811 (1990-07-01), Peter
Burger. Medicinal Chemistry, 1960, pp. 565-571, 578.581, 600-601.
Denkewalter et al., Progress In Drug Research, vol. 10, pp. 510-512.
Plattner et al., J. Med. Chem. 1988, 31(12), 2277-2288.

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