Renin inhibitors containing statine or derivatives thereof

Details Renin inhibitors containing statine or derivatives thereof Renin inhibitors containing statine or derivatives thereof

1986-03-10

1988-06-07

Phillips, Delbert K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 514 17, 530328, 530329, 530330, A61K 3743, C07K 706, C07K 508, C07K 510

Patent

active

047496878

ABSTRACT:
A series of novel peptide and polypeptide derivatives containing statine or derivatives thereof (e.g., aminostatine, cyclostatine) are disclosed that are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Of particular interest are compounds possessing the N-terminal sequence -Pro-Phe-His-Sta-Lys with the terminal proline nitrogen bonded to an amino-protecting acyl moiety or compounds possessing the N-terminal sequence -R-Phe-His-Sta-Lys- wherein R represents an amino protecting acyl group.

REFERENCES:
patent: 4304994 (1983-05-01), Veber et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4424207 (1984-01-01), Szelke et al.
patent: 4455303 (1984-06-01), Burton
patent: 4470971 (1984-09-01), Boger et al.
patent: 4478826 (1984-10-01), Veber et al.
patent: 4478827 (1984-10-01), Haber
patent: 4479941 (1984-10-01), Veber et al.
patent: 4481192 (1984-11-01), Cazaubon et al.
patent: 4485099 (1984-11-01), Boger et al.
patent: 4609643 (1986-09-01), Szelke et al.
patent: 4650661 (1987-03-01), Szelke et al.

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