Renin inhibitors containing peptide isosteres

Details Renin inhibitors containing peptide isosteres Renin inhibitors containing peptide isosteres

1984-03-27

1987-04-28

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514 18, 530332, 530329, 530330, A61K 3743, C07K 702, C07K 706

Patent

active

046614737

ABSTRACT:
Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.

REFERENCES:
patent: 4185096 (1980-01-01), Castro et al.
patent: 4216209 (1980-08-01), Bellini et al.
patent: 4218474 (1980-08-01), Barnish et al.
patent: 4269827 (1981-05-01), Burton et al.
patent: 4384994 (1983-05-01), Veber et al.
patent: 4397786 (1983-08-01), Evans et al.
Umezawa et al., Journal Antibiotics, 23:259-262, 1970.
Gross et al., Science, 175:656, 1971.
Tewksbury et al., Circulation, 59, 60, Supp., II:132, 10/79.
Poulsen et al., Biochem. Biophys. Acta, 452:533-537, 1976.
Skeggs, Jr. et al., J. Exp. Med., 106:439-453, 1957.
Kokubu et al., Biochem. Pharmacol., 22:3217-3223, 1973.
Burton et al., Biochemistry, 14:3892-3898, 1975.
Poulsen et al., Biochemistry, 12:3877-3882, 1973.
Haber and Burton, Fed. Proc. Fed. Am. Soc. Exp. Biol., 38:2768-2773, 1979.
Szelke et al., Nature, 299,555, 1982.
Szelke et al., Hypertension, 4, Supp. 2, 59, 1981.
Powers et al., Acid Proteases, Structure, Function and Biology Plenum Press, 1977, 141-157.
Tang et al., Trends in Biochem. Sci., 1:205-208, 1976.
Tang et al., J. Biol. Chem., 251:7088-94, 1976.
Ondetti and Cushman, Biopolymers, 20:2001-2010, 1981.
Ondetti et al., Chemistry and Biology of Peptides, ed., J. Meienhofer, Ann Arbor Science, pp. 525-531, 1972.
Van Lommen et al., European Peptide Symposium 16th, Peptides 1980, ed., K. Brunfeldt, Scriptor, Copenhagen, pp. 248-252, 1981.
Almquist et al., J. Med. Chem., 23:1392-1398, 1980.
Kawasaki and Maeda, Biochem. Biophys. Res. Commun., 106:113-116, 1982.
Fok and Yankellov, Biochem. Biophys. Res. Commun., 74:273-278, 1977.
Spatola and Bettag, J. Org. Chem., 46:2393-2394, 1981.
Hann et al., J. Chem. Soc. Chem. Commun., 234-235, 1980.
Cox et al., J. Chem. Soc. Chem. Commun., 799-800, 1980.
Atherton et al., J. Chem. Soc. (C), 3393-3396, 1971.
Parry et al., Chemistry and Biology of Peptides, ed., J. Meienhofer, Ann Arbor Science, pp. 541-544, 1972.
Hudson et al., Int. J. Peptide Protein Res., 15:122-129, 1979.
Frank and Desiderio, Anal. Biochem., 90:413-419, 1978.
Jacobson and Bartlett, JACS, 103:654-657, 1981.
Jennings-White and Almquist, Tet. Lett., 23:2533-2534, 1982.
Morton et al., Tet. Lett., 23:4123-4126, 1982.
Rich et al., Biochem. Biophys. Res. Comm., 104:1127-1133, 1982.
Spatola et al., Proceedings of the Seventh American Peptide Symp., ed., R. H. Rich and E. Gross, pp. 613-616, 1981.
Boger et al., Nature, 303:81-84, 1983.
Marshall, Federation Proc., 35:2494-2501, 1976.
Burton et al., Proc. Natl. Acad. Sci. U.S.A., 77:5476-5479, 9/80.
Suketa et al., Biochemistry, 14:3188, 1975.
Swales, Pharmac. Ther., 7:173-201, 1979.
Kokuba et al., Nature, 217:456-457, 2/3/68.
Matsushita et al., J. Antibiotics, 28:1016-1018, Dec. 1975.
Lazar et al., Biochem. Pharma., 23:2776-2778, 1974.
Miller et al., Biochem. Pharma., 21:2941-2944, 1972.
Harber, Clinical Science, 59:7s-19s, 1980.
Rudinger, Peptide Hormones, edited by Parsons, University Park Press, pp. 1-7.

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