Renin inhibitors containing homophe.sup.8 and a C-terminal amide

Details Renin inhibitors containing homophe.sup.8 and a C-terminal amide Renin inhibitors containing homophe.sup.8 and a C-terminal amide

1984-03-27

1987-05-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, 514 16, 514 17, 514 18, A61K 3743, C07K 512, C07K 510, C07K 508, C07K 706

Patent

active

046650520

ABSTRACT:
Renin inhibitory peptides of the formula ##EQU1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.

REFERENCES:
patent: 3784686 (1974-02-01), Miller
patent: 3873681 (1975-03-01), Miller
patent: 4384994 (1983-05-01), Veber et al.
patent: 4397786 (1983-08-01), Evans et al.
patent: 4485099 (1984-11-01), Boger et al.
Umezawa et al., J. Antibiot. (Tokyo), 23:259-262, 1970.
Gross et al., Science, 175:656, 1971.
Tewsbury et al., Circulation, 59, 60, Supp. II:132, 10/79.
Poulsen et al., Biochem. Biophys. Acta, 452:533-537, 1976.
Skeggs, Jr. et al., J. Exp. Med., 106:439-453, 1957.
Kokubu et al., Biochem. Pharmacol., 22:3217-3223, 1973.
Burton et al., Biochemistry, 14:3892-2898, 1975.
Poulsen et al., Biochemistry, 12:3877-3882, 1973.
Haber and Burton, Fed. Proc. Fed. Am. Soc. Exp. Biol., 38:2768-2773, 1979.
Hallett, Szelke, and Jones, Nature, 299, 555, 1982.
Hallett, Szelke, and Jones, Hypertension, 4, Supp. 2, 59, 1982.
Powers et al., Acid Proteases, Structure, Function and Biology, Plenum Press, 1977, 141-157.
Tang et al., Trends in Biochem. Sci., 1:205-208, 1976.
Tang et al., J. Biol. Chem., 251:7088-94, 1976.
Borger et al., Nature, 303:81-84, 1983.
Marshall, Federation Proc., 35:2494-2501, 1976.
Burton et al., Proc. Natl. Acad. Sci. USA, 77:5476-5479, 9/80.
Suketa et al., Biochemistry, 14:3188, 1975.
Swales, Pharmac. Ther., 7:173-201, 1979.
Kokubu et al., Nature, 217:456-457, 2/3/68.
Matsushita et al., J. Antibiotics, 28:1016-1018, 12/75.
Lazar et al., Biochem. Pharma., 23:2776-2778, 1974.
Miller et al., Biochem. Pharma., 21:2941-2944, 1972.
Haber, Clinical Science, 59:7s-19s, 1980.
Rich et al., J. Org. Chem., 43:3624, 1978.
Rich et al., J. Med. Chem., 23:27, 1980.
S. Takagi and K. Hayashi, Chem. Pharm. Bull. 7, 183, 1959.

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