Renin inhibitors containing C-terminal dihydroxy amides

Details Renin inhibitors containing C-terminal dihydroxy amides Renin inhibitors containing C-terminal dihydroxy amides

1989-12-04

1993-03-30

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530330, 530331, 544139, 544145, 544159, 544370, 544374, 544383, 548215, 5483147, 5483151, 5483381, 5483385, 5483127, 5483124, A61K 3702, C07K 506

Patent

active

051984261

ABSTRACT:
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, glaucoma and diseases caused by retroviruses. Processes for preparing the peptides novel intermediates in the processes, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.

REFERENCES:
patent: 4725584 (1988-02-01), Luly et al.
patent: 4853463 (1989-08-01), Iizuka et al.
patent: 4863905 (1989-09-01), Hudspeth et al.
Plattner et al. J. Med. Chem., 1988, 31(12), pp. 2277-2288.
Denkewaller et al. Progress In Drug Research vol. 10, 1966, pp. 510-512.
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601.
Tet. Lett., vol. 29, No. 32, pp. 3923-3926, 1988 Metternich et al, "New Diastereoselective Synthesis of Novel Chiral .psi.-(Aminoalkyl)-.alpha.-Hydroxy-.psi.-Lactones and Their Application for the Synthesis of Renin Inhibitors".
Journal of Medicinal Chemistry, vol. 31, No. 4, Apr. 1988, pp. 701-704.

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