Renin inhibitors containing an n-terminal disulfide cycle

Details Renin inhibitors containing an n-terminal disulfide cycle Renin inhibitors containing an n-terminal disulfide cycle

1983-09-14

1984-10-16

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

044774400

ABSTRACT:
Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.

REFERENCES:
Umezawa, et al., J. Antibiot. (Tokyo) 23: 259-262, 1970.
Gross et al., Science 175:656, 1971.
Tewksbury et al., Circulation 69, 60, Supp. II: 132, Oct. 1979.
Poulsen et al., Biochim. Biophys. Acta 452:533-537, 1976.
Skeggs, Jr. et al., J. Exp. Med. 106:439-453, 1957.
Kokubu et al., Biochem. Pharmacol. 22:3217-3223, 1973.
Burton et al., Biochemistry 14:3892-3898, 1975.
Poulsen et al., Biochemistry 12:3877-3882, 1973.
Haber and Burton, Fed. Proc. Fed. Am. Soc. Exp. Biol. 38:2768-2773, 1979.
Hypertension, 4, Supp. 2, 59, (1981).
Powers et al., Acid Proteases, Structure, Function and Biology, Plenum Press, 1977, 141-157.
Tang et al., Trends in Biochem. Sci., 1:205-208, 1976.
J. Biol. Chem. 251:7088-94, 1976.
Nakaie et al., Biochem. J. 205:43-47, 1982.
Marshall, Federation Proc. 35:2494-2501, 1976.
Burton et al., Proc. Natl. Acad. Sci. U.S.A. 77:5476-5479, Sep. 1980.
Suketa et al., Biochemistry 14:3188, 1975.
Swales, Pharmac. Ther. 7:173-201, 1979.
Kokubu et al., Nature 217:456-457, Feb. 3, 1968.
Matsushita et al., J. Antibiotics 28:1016-1018.
Lazar et al., Biochem. Pharma. 23:2776-2778, 1974.
Miller et al., Biochem. Pharma. 21:2941-2944, 1972.
Haber, Clinical Science 59:7s-19s, 1980.
Rich, et al., J. Org. Chem. 43:3624, 1978.
J. Med. Chem. 23:27, 1980.

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