Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1991-03-28
1992-06-30
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C07D29526, A61K 3700
Patent
active
051264510
ABSTRACT:
The invention concerns novel renin-inhibitory peptides which contain novel amino acids having an .alpha.-heteroatom attached to the backbone of the amino acid. ##STR1## These novel amino acids are positioned at the P.sub.2 position of the peptide. These are useful for treating renin-associated hypertension, hyperaldosteronism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Novel intermediates are also disclosed. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.
REFERENCES:
Tetrahedron, v. 31, pp. 863 to 866, U. Zoller et al., "Amidoalkylation of Mercaptans with Glyoxylic . . . ".
J. Org. Chem., 1986, 51, 3718-3720, M. G. Bock et al., "Differentially Protected .alpha.-Aminoglycine".
Kaltenbronn James S.
Repine Joseph T.
Anderson Elizabeth M.
Berch Mark L.
Warner-Lambert & Company
LandOfFree
Renin inhibitors containing .alpha.-heteroatom amino acids does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Renin inhibitors containing .alpha.-heteroatom amino acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Renin inhibitors containing .alpha.-heteroatom amino acids will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1864885