Renin inhibitors containing alpha-heteroatom amino acids

Details Renin inhibitors containing alpha-heteroatom amino acids Renin inhibitors containing alpha-heteroatom amino acids

1988-06-06

1991-07-30

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

544 86, 544162, 564123, 564152, 564161, 564163, 530331, 514 18, A61K 3702, C07K 506, C07K 508

Patent

active

050360540

ABSTRACT:
The invention concerns novel renin-inhibitory peptides which contain novel amino acids having an .alpha.-heteroatom attached to the backbone of the amino acid. These novel amino acids are positioned at the P.sub.2 position of the peptide. These are useful for treating renin-associated hypertension, hyperaldosteronism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Novel intermediates are also disclosed. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.

REFERENCES:
patent: 4839357 (1989-06-01), Patchett et al.
Burger. Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601.
Denkewalter et al., Progress in Drug Research, vol. 10, 1966, pp. 610-612.
Plattner et al., J. Med. Chem., 1988, 31 (12), 2277-2288.
European Search Report.

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