Renin inhibitors containing a C-terminal amide cycle

Details Renin inhibitors containing a C-terminal amide cycle Renin inhibitors containing a C-terminal amide cycle

1983-06-15

1984-11-27

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

044850999

ABSTRACT:
Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.

REFERENCES:
Umezawa et al., J. Antibiot., (Tokyo), 23:259-262, 1970.
Gross et al., Science, 175:656, 1971.
Tewksbury et al., Circulation, 59, 60, Supp. II: 132, Oct. 1979.
Poulsen et al., Biochem. Biophys. Acta, 452:533-537, 1976.
Skeggs et al., J. Exp. Med., 106:439-453, 1957.
Kokubu et al., Biochem. Pharmacol., 22:3217-3223, 1973.
Burton et al., Biochemistry, 14:3892-3898, 1975.
Poulsen et al., Biochemistry, 12:3877-3882, 1973.
Haber and Burton, Fed. Proc. Fed. Am. Soc. Exp. Biol., 38:2768-2773, 1979.
Szelke et al., Hypertension, 4, Supp. 2, 59-69, (1981).
Powers et al., Acid Proteases, Structure, Function and Biology, Plenum Press, 1977, 141-157.
Tang et al., Trends in Biochem. Sci., 1:205-208, (1976).
Marciniszyn et al., J. Biol. Chem., 251:7088-94, 1976.
Marshall, Federation Proc., 35:2494-2501, 1976.
Burton et al., Proc. Natl. Acad. Sci., USA, 77:5476-5479, 9/80.
Suketa & Inagami, Biochemistry, 14:3188-3194, 1975.
Swales, Pharmac. Ther., 7:173-201, 1979.
Kokubu et al., Nature, 217:456-457, Feb. 3, 1968.
Matsushita et al., J. Antibiotics, 28:1016-1018, Dec. 1975.
Lazar et al., Biochem. Pharma., 23:2776-2778, 1974.
Miller et al., Biochem. Pharmac., 21:2941-2944, 1972.
Haber, Clinical Science, 59:7s-19s, 1980.
Rich et al., J. Org. Chem., 43:3624-3626, 1978.
Rich & Sun, J. Med. Chem., 23:27-33, 1980.
TIPS-May 1982, pp. 211-212; Substance P-Antagonist: A New Type of Pharmacological Tool, Sune Rosell and Karl Folkers.

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