Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxyp

Details Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxyp Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxyp

1987-11-02

1990-08-14

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260404, 560 28, 560 29, 560160, C07C125065

Patent

active

049489135

ABSTRACT:
A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these compounds are certain other 5-amino-2,5-disubstituted-4-hydroxypentanoic acid derivatives.

REFERENCES:
patent: 4487963 (1984-12-01), Bock
patent: 4803292 (1989-02-01), Ohfune
patent: 4814485 (1989-03-01), Descamps

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